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Provigil En France
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Il n'est pas clair si le modafinil a un rôle dans la modulation des rythmes circadiens. Le modafinil est principalement métabolisé dans le foie et les reins. L'effet sur l'inhibition est un mécanisme similaire à l'amphétamine et à la cocaïne, mais sans les dommages causés par les amphétamines et la cocaïne aux neurones. Les résultats antérieurs d'efficacité comprenaient des améliorations des performances neurocognitives, de la mémoire, de la coordination motrice et de la vigilance. Il est efficace contre de nombreux médicaments couramment utilisés pour traiter les troubles du sommeil, notamment les agonistes de l'adénosine, les antihistaminiques, les benzodiazépines et le méthylphénidate. Il est généralement bien toléré, bien qu'il ait été associé à des effets indésirables tels que des hallucinations et des changements de comportement et plus rarement à une hypotension, une anorexie et une arythmie cardiaque (par exemple, une hyperkaliémie). La structure exacte du modafinil dépend de l'énantiomère à partir duquel il est fabriqué. Provigil En France L'arrêt est recommandé dès les premiers signes d'éruption cutanée ou de réactions similaires. Les effets secondaires graves peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Le modafinil et l'armodafinil peuvent provoquer un effet d'éveil plus constant que l'amphétamine ou le méthylphénidate, qui provoquent des sensations d'énergie et d'excitation plus fortes. Contrairement aux amphétamines, le modafinil n'aggrave pas la dépression et ne crée pas de dépendance. Pour la narcolepsie, il a été démontré que le modafinil augmente le temps passé en sommeil non paradoxal au cours duquel le cerveau est déclenché, ce qui est censé être conforme à la vigilance accrue et à la réduction de la somnolence diurne résultant du sommeil non paradoxal précoce ( stades 1 et 2) et le sommeil à mouvements oculaires rapides (REM). Une fois dans le SNC, la dopamine exerce une influence sur diverses structures clés impliquées dans la régulation de l'attention, de la mémoire et de l'humeur. Le modafinil ne doit pas être utilisé pendant plus de deux semaines à la fois. Au contraire, le modafinil agit pour favoriser l'éveil. Le nouveau composé était administré à des narcoleptiques qui étaient devenus somnolents pendant la journée et commençaient à présenter une cataplexie. Le modafinil est un médicament relativement sûr.
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