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Modafinil Prix
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Modafinil Prix
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Il est produit sous forme d'énantiomère R-(-) du 2-(benzhydrylsulfinyl)acétamide. Le modafinil est un agoniste dopaminergique faible et un agoniste complet des récepteurs dopaminergiques D2 et D3, mais aucun agoniste des récepteurs dopaminergiques D1 et D4. Il a ensuite été commercialisé sous le nom de Concerta au Canada et a d'abord été vendu sous le nom de marque Nuvigil dans le reste du monde. Le modafinil est un mélange racémique avec un énantiomère R et S et un certain nombre d'isomères optiques, mais l'activité biologique réside dans l'énantiomère S le plus actif. Habituellement, ces troubles sont causés par des troubles du sommeil tels que l'apnée du sommeil ou la narcolepsie, mais il peut également être utilisé dans d'autres cas. En doses quotidiennes, il est pris sous forme de 1-2 comprimés de 100 mg. Le modafinil a été étudié pour le traitement de diverses indications, notamment le trouble déficitaire de l'attention, la narcolepsie et la mémoire à court terme. La posologie est basée sur le poids corporel et d'autres facteurs. Il ne semble pas altérer la sensibilité des récepteurs ou provoquer une désensibilisation des récepteurs. Le métabolisme in vitro avec le CYP3A4 recombinant a montré qu'au niveau thérapeutique, seulement 10 % du médicament parent est métabolisé. Le modafinil a été approuvé par la FDA pour être utilisé comme thérapie initiale pour le traitement chez l'adulte de la somnolence excessive associée à la narcolepsie et aux troubles du sommeil liés au travail posté. La Classification internationale des maladies (CIM) considère la narcolepsie comme un trouble neurologique chronique, tandis que l'Organisation mondiale de la santé la considère comme un trouble du cycle veille-sommeil. Bien qu'il existe certaines preuves de son efficacité en tant qu'amplificateur cognitif, il n'y a aucune preuve solide que le modafinil améliore le fonctionnement cognitif. Le modafinil est également utilisé comme traitement des troubles du sommeil liés au travail posté. Il est également disponible en gélule et en comprimé mou. Modafinil Prix Le modafinil est un médicament systémique qui traverse la barrière hémato-encéphalique. Il existe des preuves suggérant que le modafinil pourrait être un traitement prometteur pour d'autres troubles du sommeil, notamment la dépression majeure et l'apnée obstructive du sommeil. Le modafinil est le sel de sodium du 2-[(diphénylméthyl)sulfinyl]méthyl-2,3,4,5-tétrahydro-1H-1-benzazépin-7-ol. Modafinil est disponible sous diverses formes. Ceci est réalisé en bloquant le transporteur de dopamine présynaptique. Modafinil a été développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon à Ciboure. Le modafinil est généralement pris par voie orale, bien qu'il ait été utilisé par voie topique. C'est l'un des traitements les plus efficaces pour les travailleurs postés. Les chercheurs émettent l'hypothèse que la production d'hormone de croissance par l'organisme est causée par le stress et que les suppléments d'hormone de croissance en milieu industriel sont une réponse à un excès de stress. Le modafinil peut être utilisé seul ou avec d'autres médicaments. Le modafinil est un stimulant du système nerveux central.
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