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Nootropique En France
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La dose quotidienne totale ne doit pas dГ©passer 400 mg pour les patients prenant du modafinil pour la narcolepsie et 400 mg pour les patients prenant du modafinil pour le travail postГ© ou le dГ©calage horaire. En tant que mГ©dicament, il est utilisГ© pour traiter la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. C'est un stimulant qui dure plus longtemps que les autres stimulants du SNC couramment utilisГ©s tels que l'amphГ©tamine et le modafinil. Le modafinil peut ГЄtre disponible en tant que mГ©dicament gГ©nГ©rique. п»їModafinil contient un mГ©lange d'Г©nantiomГЁres. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©. Dans les tests cellulaires, le modafinil a montrГ© une puissance rГ©duite par rapport Г un certain nombre d'autres systГЁmes de monoamine, y compris la sГ©rotonine, la noradrГ©naline et la phГ©nylГ©thylamine, mais pas la dopamine. Il agit en augmentant les niveaux d'adГ©nosine monophosphate cyclique (AMPc) pour inhiber la recapture de la dopamine et de la noradrГ©naline. En plus des risques cardiovasculaires associГ©s Г tout stimulant, le modafinil peut prГ©disposer Г la mort subite chez les personnes prГ©sentant des anomalies soudaines du rythme cardiaque. Le mГ©canisme exact de son efficacitГ© n'est pas connu. Votre mГ©decin voudra peut-ГЄtre rГ©duire la dose. Le modafinil semble agir en agissant sur la dopamine et en modulant les zones du cerveau impliquГ©es dans le cycle du sommeil. Le mГ©dicament est blanc Г blanc cassГ© et a un goГ»t lГ©gГЁrement amer. Modafinil HCl, un sel HCl, est le plus couramment prescrit, et sa chimie a Г©tГ© dГ©terminГ©e par Cyril I. Nootropique En France Provigil est fabriquГ© par Sun Pharmaceutical Industries. La demi-vie d'Г©limination du composГ© parent et de son mГ©tabolite actif, le M200, aprГЁs administration orale s'est avГ©rГ©e ГЄtre de 2 heures. Des avantages modestes sur la cognition et l'humeur Г©taient Г©vidents avec le modafinil dans les troubles du sommeil, et il a Г©tГ© examinГ© dans des essais sur la dГ©pression, la narcolepsie et pour une utilisation dans le travail postГ© et le dГ©calage horaire. Un jury a conclu que le fabricant, Mitsubishi Chemical, n'avait pas averti que le modafinil pouvait rendre l'enfant hyperactif et qu'il avait peut-ГЄtre endommagГ© son cerveau. L'ingrГ©dient actif dans les trois dosages est le modafinil. Le citrate de modafinil (R,S)-2-(diphГ©nylmГ©thyl)-N-mГ©thyl-1-acГ©tamino-cyclopropanecarboxamide, ou citrate de modafinil, est un stimulant du systГЁme nerveux central et un agent favorisant l'Г©veil qui stimule sГ©lectivement les rГ©cepteurs de l'histamine-1. Cependant, en Europe et dans d'autres pays, la dose est de 250 mg et 350 mg. La marque la plus courante de Modafinil aux Г‰tats-Unis est Provigil. On estime que le modafinil a une demi-vie de 5 Г 6 heures. Il est Г©galement connu sous le nom d'almodafinil, mais la littГ©rature ne fait pas la distinction entre ces deux formes.
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